As Dieter suggests, setting up alerts and then using the Alert Viewer portlet would be a good way to track irregular system behavior. You could even setup email notifications as an associated alert action.
Other portlets to consider would be the trending portlets, Metrics Graph and Capacity Heatmap, where you can monitor overall CPU usage or other metrics to see where system usage increases.
Query Spotlight allows management of queries of concern over durations of time so this should definately be part of your analysis tools.
Also consider the Todays Statistics portlet for easy comparison of what happens today against the same time frame a week ago.
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